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Dr Jennifer Thompson

jennifer.thompson@manchester.ac.uk

Dr Jennifer Thompson is a neuropsychologist at the Cerebral Function Unit, Greater Manchester Neuroscience Centre. In this clinical and research role she carries out highly specialised neuropsychological assessments of patients attending the unit and is involved in a number of ongoing research studies investigating clinical, neuropsychological and behavioural aspects of neurodegenerative disorders, including Alzheimer's disease, Huntington's disease, frontotemporal dementia and semantic dementia.

Publications

Sitek, E.J., Thompson, J.C., Craufurd, D., Snowden, J.S. (2014). Unawareness of deficits in Huntington’s disease. Journal of Huntington’s Disease, 3, 125-135.

Davidson, Y., Barker, H., Robinson, A.C., Thompson, J.C., Harris, J., Troakes, C., Smith, B., Al-Saraj, S., Shaw, C., Rollinson, S., Masuda-Suzukake, M., Hasegawa, M., Pickering-Brown, S., Snowden, J.S., Mann, D.M.A. (in press) Brain distribution of dipeptide repeat proteins in frontotemporal lobar degeneration and motor neurone disease associated with expansions in C9ORF72. Acta Neuropathologica Communications.

Lant, S.B., Robinson, A.C., Thompson, J.C., Rollinson, S., Pickering-Brown, S., Snowden, J.S., Davidson, Y.S., Gerhard, A., Mann, D.M.A. (2013) Patterns of microglial cell activation in Frontotemporal lobar degeneration. Neuropathology and Applied Neurobiology. doi: 10.1111/nan.12092

Mann, D.M.A., Rollinson, S., Robinson, A., Bennion Callister, J., Thompson, J.C., Snowden, J.S., Gendron, T., Petrucelli, L., Masuda-Suzukake, M., Hasegawa, M., Davidson, Y., Pickering-Brown, S. Dipeptide repeat proteins are present in the p62 positive inclusions in patients with frontotemporal lobar degeneration and motor neurone disease associated with expansions in C9orf72. (2013) Acta Neuropathologica Communications, 1, 68.

Harris, J.M., Thompson, J.C., Gall, C., Richardson, A.M.T., Neary, D., du Plessis, D., Pal, P., Mann, D.M.A., Snowden, J.S., Jones, M. (in press). Do NIA-AA criteria distinguish Alzheimer’s disease from frontotemporal dementia? Alzheimer’s and Dementia.

Harris, J.M., Gall, C., Thompson, J.C., Richardson, A.M.T., Neary, D., du Plessis, D., Pal, P., Mann, D.M.A., Snowden, J.S., Jones, M. (2013). Classification and Pathology of Primary Progressive Aphasia. Neurology, 81, 1832-9.

Harris, J.M., Gall, C., Thompson, J.C., Richardson, A.M.T., Neary, D., du Plessis, D., Pal, P., Mann, D.M.A., Snowden, J.S., Jones, M. (2013). Sensitivity and specificity of FTDC criteria for frontotemporal dementia. Neurology, 80, 1881-7

Kobylecki, C., Gerhard, A., Thompson, J.C., Hughes, D., O’Driscoll, K. (2013). Giant serpentine aneurysm of the anterior cerebral artery mimicking frontotemporal dementia. Journal of Neurology, 260, 1163-1165.

Snowden, J.S., Harris, J., Richardson, A., Rollinson, S., Thompson, J.C., Neary, D., Mann, D.M.A., Pickering-Brown, S. (2013). Frontotemporal dementia with amyotrophic lateral schlerosis: a clinical comparison of patients with and without repeat expansions in C9ORF72. Amyotrophic Lateral Sclerosis and Frontotemporal Dementia, 14, 172-176.

Kobylecki, C., Thompson, J.C., Jones, M., Mills, S.J., Shaunak, S., Ironside, J.W., Snowden, J.S., Richardson, A.M. (2013). Sporadic Creutzfeldt-Jakob disease presenting as progressive non-fluent aphasia with speech apraxia. Alzheimer’s disease and associated disorders, 27, 384-6.

Snowden, J.S., Rollinson, S., Lafon, C., Harris, J., Thompson, J.C., Richardson, A.M.T., Jones, M., Gerhard, A., Neary, D., Mann, D.M.A., Pickering-Brown, S. (2012). Psychosis, C9ORF72 and Dementia with Lewy Bodies. Journal of Neurology, Neurosurgery and Psychiatry, 83, 1031-1032.

Snowden, J.S., Kindell, J., Thompson, J.C. Richardson, A.M.T., Neary, D. (2012). Progressive aphasia  presenting with deep dyslexia and dysgraphia. Cortex, 48, 1234-1239.

Thompson, J.C. Harris, J., Sollom, A., Stopford, C.L., Howard, E., Snowden, J.S. Craufurd, D. (2012). Longitudinal evaluation of neuropsychiatric symptoms in Huntington’s disease. Journal of Neuropsychiatry and Clinical Neuroscience, 24, 53-60.

Snowden, J.S. Rollinson, S., Thompson, J.C., Harris, J., Stopford, C., Richardson, A., Jones, M., Gerhard, A., Davidson, Y., Robinson, A., Gibbons, L., Hu, Q., Halliwell, N., DuPlessis, D., Neary., D., Mann, D.M.A., Pickering-Brown, S. (2012). Distinct clinical characteristics in patients with frontotemporal dementia and C9ORF72 mutations: a study of demographics, neurology, behaviour, cognition, and histopathology. Brain, 135, 693-708.

Foulds, P.G., Yokota, O., Thurston, A., Davidson, Y., Ahmed, Z., Holton, J., Thompson, J.C., Akiyama, H., Arai, T., Hasegawa, M., Gerhard, A., Allsop, D., Mann, D.M.A. (2012). Post mortem cerebrospinal fluid α-synuclein levels are raised in multiple system atrophy and distinguish this from the other α-synucleinopathies, Parkinson's disease and Dementia with Lewy bodies. Neurobiology of Disease, 45, 188-195.

Snowden, J.S., Thompson, J.C., Neary, D. (2012). Famous people knowledge and the right and left temporal lobes. Behavioural Neurology, 25, 35-44.

Davidson, Y.S., Raby, S., Foulds, P.G., Robinson, A., Thompson, J.C., Sikkink, S., Yusef, I., Amin, H., DuPlessis, D., Troakes, C., Al-Sarraj, S., Esiri, M.M., Prasher, V.P., Allsop, D., Neary, D., Snowden, J.S., Mann, D.M.A. (2011). TDP-43 pathological changes in early onset familial and sporadic Alzheimer’s disease, late onset Alzheimer’s disease and Down’s syndrome: association with age and clinical phenotype. Acta Neuropathologica,122, 703-713.

Snowden, J.S., Thompson, J.C., Stopford, C.L., Richardson, A.M.T., Gerhard, A., Neary, D., Mann, D.M.A. (2011). The clinical diagnosis of early-onset dementias: diagnostic accuracy and clinicopathological relationships. Brain,135, 693-708.

Stopford, C.S., Thompson, J.C., Richardson, A.M.T., Neary, D., Snowden, J.S. (2010). Working memory in Alzheimer’s disease and frontotemporal dementia. Behavioural Neurology, 23, 177-179.

Vardy, E.R.L.C., Brown, K., Stopford, C.L., Thompson, J.C., Richardson, A.M.T., Neary, D., Kalsheker, N., Morgan, K., Mann, D.M.A, Snowden, J.S. (2010). Cognitive phenotypes in Alzheimer’s disease and genetic variants in ACE and IDE. Neurobiology of Aging. doi:10.1016/j.neurobiolaging.2010.11.003

Baboriel, A., Griffiths, T.D., Jaros, E., McKeith, I.G., Burn, D., Richardson, A., Ferrari, R., Moreno, J., Momeni, P., Duplessis, D., Pal, P., Rollinson, S., Pickering-Brown, S., Thompson, J.C., Neary, D., Snowden, J.S., Perry, R., Mann, D.M.A. (2011). Pathological correlates of frontotemporal lobar degeneration in the elderly. Acta Neuropathologica, 121, 365-371.

Stopford, C.L., Thompson, J.C., Neary, D. Richardson, A.M.T. & Snowden, J.S. (2010). Working memory, attention and executive function in Alzheimer’s disease and frontotemporal dementia. Cortex. DOI: 10.1016/j.cortex.2010.12.002

Julien, C.L., Thompson, J.C., Neary, D., & Snowden, J.S. (2010). Understanding quantity in semantic dementia. Cognitive Neuropsychology, 27, 3-29.

Thompson, J.C., Poliakoff, E., Sollom, A.C., Howard, E., Craufurd, D., & Snowden, J.S. (2010) Automaticity and attention in Huntington’s disease: when two hands are not better than one. Neuropsychologia, 48, 171-178.

Julien, C.L., Thompson, J.C., Neary, D., Snowden, J.S. (2008). Arithmetic knowledge in semantic dementia: Is it invariably preserved? Neuropsychologia, 46, 2732-2744.

Snowden, J.S., Austin, N.A., Sembi, S., Thompson, J.C., Craufurd, D., Neary, D (2008). Emotion recognition in Huntington's disease and frontotemporal dementia. Neuropsychologia, 46, 2638-2649.

Stopford, C.L., Snowden, J.S., Thompson, J.C., Neary, D. (2008). Variability in cognitive presentation of Alzheimer’s disease. Cortex, 44, 185-195.

Stopford, C.L., Snowden, J.S., Thompson, J.C., Neary, D. (2007). Distinct memory profiles in Alzheimer’s disease. Cortex, 43, 846-857.

Gibbons, Z.C., Snowden, J.S., Thompson, J.C., Happé, F., Richardson, A., Neary, D. (2007). Inferring thought and action in motor neuron disease. Neuropsychologia, 45, 1196-1207.

Julien, C.L., Thompson, J.C., Wild, S., Yardumian, P., Snowden, J.S., Turner, G., & Craufurd, D. (2007). Psychiatric disorders in pre-clinical Huntington's disease. Journal of Neurology, Neurosurgery and Psychiatry, 78, 939-943.

Snowden, J.S., Stopford, C., Julien, C., Thompson, J.C., Davidson, Y., Gibbons, L., Prichard, A., Lendon, C.L., Richardson, A., Varma, A., Neary, D., Mann, D.M.A. (2007). Cognitive phenotypes in Alzheimer’s disease and Genetic Risk. Cortex, 44, 185-195.

Davidson Y, Gibbons L, Pritchard A, Hardicre J, Wren J, Stopford C, Julien C, Thompson J, Payton A, Pickering-Brown SM, Pendleton N, Horan MA, Burns A, Purandare N, Lendon CL, Neary D, Snowden JS, Mann DMA. (2007). Apolipoprotein E ε4 allele frequency and age at onset of Alzheimer's disease. Dementia and Geriatric Cognitive Disorders, 23, 60-66.

Davidson, Y., Gibbons, L., Pritchard, A., Wren, J., Tian, J., Shi, J., Stopford, C., Julien, C., Thompson, J., Payton, A., Thaker, U., Hayes, A.J., Iwatsubo, T., Pickering-Brown, S.M., Pendleton, N., Horan, M.A., Burns, A., Purundare, N.B., Lendon, C.L., Neary, D., Snowden, J.S., & Mann, D.M.A. (2006). Genetic associations between cathepsin D exon 2 C→ T polymorphism and Alzheimer’s disease and pathological correlations with genotype. Journal of Neurology, Neurosurgery and Psychiatry, 77, 515-517.

Shi, J., Shaw, C.L., Du Plessis, D., Richardson, A.M.T., Bailey, K.L., Julien, C., Stopford, C., Thompson, J., Varma, A., Craufurd, D., Tian, J., Pickering-Brown, S., Neary, D., Snowden, J.S., Mann, D.M.A. (2006). Histopathological changes underlying frontotemporal lobar degeneration with clinicopathological correlation. Acta Neuropathologica, 110, 501-12.

Srinivasan, R., Davidson, Y., Gibbons, L., Payton, A., Richardson, A.M.T., Varma, A., Julien, C., Stopford, C., Thompson, J., Horan, M.A., Pendleton, N., Pickering-Brown, S.M., Neary, D., Snowden, J.S., Mann, D.M.A. (2006). The apolipoprotein E 4 allele selectively increases the risk of frontotemporal lobar degeneration in males. Journal of Neurology, Neurosurgery and Psychiatry, 77, 154 - 158.

Thompson, J.C., Stopford, C.L., Snowden, J.S., & Neary, D. (2005). Qualitative neuropsychological performance characteristics in frontotemporal dementia and Alzheimer’s disease. Journal of Neurology, Neurosurgery and Psychiatry, 76, 920-927.

Snowden, J.S., Thompson, J.C., & Neary, D. (2004). Knowledge of famous faces and names in semantic dementia. Brain, 127, 860-872.

Ho, A.K., Sahakian, B.J., Brown, R.G., Barker, R.A., Hodges, J.R., Ané, M.-N., Snowden, J.S., Thompson, J., Esmonde, T., Gentry, R., Moore, J.W., & Bodner, T. (2003). Profile of cognitive progression in early Huntington's disease. Neurology, 61, 1702-6.

Snowden, J.S., Gibbons, Z.C., Blackshaw, A., Doubleday, E., Thompson, J., Craufurd, D., Foster, J., Happé, F., & Neary D. (2003). Social cognition in frontotemporal dementia and Huntington’s disease. Neuropsychologia, 41, 688-701.

Thompson, J.C., Beswick, T., Foster, J.K., & Snowden, J.S. (2003). New learning and remote memory in atypical Alzheimer's disease. Cortex, 39, 751-66.

Snowden, J.S., Craufurd, D., Thompson, J., Neary, D. (2002). Psychomotor, executive and memory function in preclinical Huntington's disease. Journal of Clinical and Experimental Neuropsychology, 24, 133-145.

Thompson, J.C., Snowden, J.S., Craufurd, D., (2002). Neary, D. Behavior in Huntington's disease: dissociating cognition-based and mood-based changes. Journal of Neuropsychiatry and Clinical Neurosciences, 14, 37-43.

Craufurd, D., Thompson, J.C., Snowden, J.S. (2001). Behavioural change in Huntington's disease. Neuropsychiatry, Neuropsychology and Behavioural Neurology, 14, 219-226.

Snowden, J.S., Craufurd, D., Griffiths, H.L., Thompson, J., & Neary, D. (2001). Longitudinal evaluation of cognitive disorder in Huntington's disease. Journal of the International Neuropsychological Society, 6, 33-44.